Description of product

Farmaction.

Contraceptive drug. Inhibits secretion of pituitary gonadotropin-releasing hormone. The contraceptive effect is due to the influence on the hypothalamic-pituitary-ovarian system. Ethinylestradiol - a synthetic analogue of the follicular hormone estradiol is involved with progesterone in the implementation of the menstrual cycle. Progestogenic drug (desogestrel) inhibits the synthesis of LH and FSH by the pituitary gland (to prevent maturation of the follicle) and thus blocks ovulation. In addition to these central and peripheral mechanisms of preventing the maturation able to fertilize the egg, contraceptive effect is due to decrease in the susceptibility of the endometrium to blastocyst and increasing the viscosity of mucus, located in the cervix, making it relatively impenetrable to sperm. Has beneficial effects on lipid metabolism: it increases the concentration of HDL in plasma, without affecting the content of LDL. The treatment showed a significant decrease in the amount of blood lost (during the initial menorrhagia). Has a beneficial effect on the skin, especially improving its status in the vulgar acne, when taken regularly and has a therapeutic effect by normalizing the menstrual cycle and contributing to the prevention of a number of gynecological diseases, including neoplastic nature.

Indications.

Contraception.

Contraindications.

Hypersensitivity, venous or arterial thrombosis / thromboembolism (including deep vein thrombosis leg, pulmonary embolism, myocardial infarction, stroke), including history, the harbingers of thrombosis (including transient ischemic attack, angina), including a history of migraine with focal neurological symptoms in the history of diabetes mellitus with vascular lesions, the presence of severe or multiple risk factors for venous or arterial thrombosis (including severe hypertension with blood pressure 160/100 mm Hg or more) pancreatitis (including history), accompanied by severe hypertriglyceridemia, severe liver disease (up to normalization of liver function parameters), including a history of liver tumors, including a history of hormone-dependent malignancies of genital organs and mammary glands (including suspects), vaginal bleeding of unknown etiology, smokers older than 35 years (more than 15 cigarettes a day), pregnancy (including estimated), lactation .

With caution.

State, increase the risk of venous or arterial thrombosis / thromboembolism: age older than 35 years, smoking, family history, obesity (body mass index over 30 kg / m), dislipoproteinemia, hypertension, migraine, valvular heart disease, atrial fibrillation, prolonged immobilization, major surgery, surgery of the lower extremities, severe trauma, varicose veins and superficial thrombophlebitis, postpartum period, changes in biochemical parameters (activated protein C resistance, hyperhomocysteinemia, deficiency of antithrombin III, protein C deficiency or S, antiphospholipid antibodies, including antibodies to cardiolipin, lupus anticoagulant). Diabetes, lupus, hemolytic uremic syndrome, Crohn's disease, ulcerative colitis, sickle cell anemia, hypertriglyceridemia (including family history), acute and chronic liver disease, including congenital hyperbilirubinemia (Gilbert's syndrome, Dubin-Johnson, Rotor) to restore biochemical parameters.

Dosing.

Inside, squeezed liquid, 1 tablet per day (starting no later than 5 day cycle, 1 cycle day - this is a day of menstruation) daily at the same time, without interruption, for 21 days, then take a break 7 days. In the first 14 days you must use additional contraceptive measures.

If from the onset of menstruation has been more than 5 days, then begin taking tablets from the next cycle. After delivery, the drug should be started on the first day of the first self-menstruation. After a miscarriage or abortion drug must be taken immediately. Full contraceptive action remains subject to systematic tablets (maximum delay - no more than 12 h). If it has been more time, then the next day at the usual time it should take 2 tablets of the drug, but to use additional contraception for the next 14 days or until the next menstruation.

Side effects.

Thrombosis or thromboembolism (including myocardial infarction, stroke, deep vein thrombosis, pulmonary embolism). Chloasma (especially if there is a history of chloasma during pregnancy), Crohn's disease, ulcerative colitis, intermenstrual bleeding (spotting or heavy) in the first months of the drug, allergic reactions.

Relationship with the drug intake is not installed: thromboembolism hepatic, mesenteric, renal, retinal arteries and veins, headache, migraine, changes in libido, emotional lability, depression, impaired function of the gastrointestinal tract, including nausea, vomiting, pain, enlargement and breast engorgement, galactorrhea, weight gain, fluid retention, increased blood pressure, skin rash, erythema, or erythema, intolerance to contact lenses, changes in vaginal secretion; emergence or exacerbation of jaundice and / or itching associated with cholestasis, cholelithiasis, porphyria, lupus erythematosus, hemolytic uremic syndrome, chorea, gestational herpes, hearing loss due to otosclerosis.

Overdose.

Symptoms: nausea, vomiting, girls - bloody discharge from the vagina.

Treatment: symptomatic.

Interaction.

Drugs that induce hepatic enzymes such as hydantoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, drugs containing St John's wort reduces the effectiveness of ordinary oral contraceptives and increased risk of bleeding "breakthrough." The maximum level of induction is usually achieved no earlier than 2-3 weeks, but can last up to 4 weeks after drug withdrawal.

Ampicillin, tetracycline - reduce the effectiveness of (the mechanism of interaction is not installed).

If necessary, a joint reception, it is recommended to use an additional barrier method of contraception during treatment and for 7 days (for rifampicin - within 28 days) after drug withdrawal.

Special instructions.

Before and every 6 months of preparation is recommended to general medical and gynecological examination (including pelvic control study of breast, liver function, blood pressure control and cholesterol in the blood, urine). Is a reliable contraceptive drugs: Pearl Index (number of pregnancies that occurred during the application of the method of contraception in 100 women over 1 year) - 0.05. Due to the fact that the contraceptive effect of the drug from the beginning of the reception is fully manifested by 14 days, in the first 2 weeks of treatment is recommended to apply an additional non-hormonal methods of contraception.

After acute viral hepatitis should be taken after normalization of liver function (not earlier than 6 months). Diarrhea or intestinal disorders, vomiting contraceptive effect may be reduced (without stopping the drug, it is necessary to use additional non-hormonal methods of contraception). Women who smoke have an increased risk of cardiovascular disease with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women older than 35 years) and the number of cigarettes smoked. During the period of lactation may reduce the milk in small amounts excreted in breast milk. Estrogen drugs increase the risk of thrombosis in women who have undergone surgery or prolonged immobilization. Women who have been chloasma should avoid exposure to the sun.